He worked at Texas Instruments, Engim, National Semiconductor and Analog Devices. He joined MediaTek, Woburn, MA, USA, in 2021, as a Director of Technology.

He coauthored more than 70 peer-reviewed papers and three books, notably Advanced Data Converters (Cambridge University Press, 2011), and has been granted 20 U.S. patents.

He was a recipient of scientific awards, including the 1995 CEU Award from the Rutherford Appleton Laboratory, U.K., the 1999 IEEE Circuits and Systems Outstanding Young Author Award, and the 2007 IEEE European Solid-State Circuits Conference Best Paper Award.

Dr. Manganaro was elevated to IEEE Fellow in 2016 and IET Fellow in 2009 and is a member of the Sigma Xi scientific honor society. He currently serves as the Vice-President for Publications for the IEEE Circuits and Systems Society (CASS) for 2023–2026 and is a Distinguished Lecturer for the IEEE Solid-State Circuits Society (2019–2020, 2026–2027). His editorial service includes roles as Editor-in-Chief (2012–2013) for the IEEE Transactions on Circuits and Systems I: Regular Papers, following tenures as Associate and Deputy Editor-in-Chief. He was also the inaugural Editor-in-Chief for the IEEE Open Journal of Circuits and Systems (2020–2022). Additionally, he served on the ISSCC Data Converters Technical Sub-Committee (2005–2012), the IEEE CASS Board of Governors (2016–2018), and has been an Industry Advisory Member for the Proceedings of the IEEE (2019–2024), as well as a member of multiple technical committees for the Semiconductor Research Corporation since 2019.