From 1999 to 2000, he was with Texas Instruments, Dallas, TX, where he worked on the design of mixed-signal integrated circuits for high-speed serial data communication. From 2006 to 2008, he was with Intel Corporation, Hillsboro, OR, USA, where he worked on high-speed optical and electrical I/O architectures.

In 2009, he joined the Electrical and Computer Engineering Department, Texas A&M University, College Station, TX, USA, where he is currently the J. W. Runyon Jr. Professor. His research interests include high-speed electrical and optical interconnect architectures, RF photonics, high-performance clocking circuits integrated sensor systems, and neuromorphic computing systems.

Dr. Palermo is currently an associate editor for IEEE Journal of Solid-State Circuits and has previously served in this role for IEEE Solid-State Circuits Letters and IEEE Transactions on Circuits and System – II. He has also previously served as a distinguished lecturer for the IEEE Solid-State Circuits Society and on the IEEE CASS Board of Governors. He was a co-author of the Jack Raper Award for Outstanding Technology-Directions Paper at the 2009 International Solid-State Circuits Conference, the Best Student Paper at the 2014 Midwest Symposium on Circuits and Systems, an Outstanding Student Paper Award at the 2018 Custom Integrated Circuits Conference, and the Best Student Paper Award at the 2024 Opto-Electronics and Communications Conference.